Journal
AIDS RESEARCH AND HUMAN RETROVIRUSES
Volume 29, Issue 8, Pages 1161-1167Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2012.0367
Keywords
-
Categories
Funding
- RIS: Red Tematica Cooperativa de Grupos de Investigacion en Sida del Fondo de Investigacion Sanitaria (FIS) [EC10-153, PI10/02984, TRA-094, FIS PS09/01297, FIS 07/0291]
- ISCIII (Instituto de Salud Carlos III)
- Health Department of the Catalan Government (Generalitat de Catalunya)
Ask authors/readers for more resources
The reduction of risk of non-AIDS events after combined antiretroviral therapy (cART) initiation and the crude incidence rate (CIR) of these events in patients who control the viral load without cART (controllers) in a cohort of 574 antiretroviral-naive patients with a baseline CD4 T cell count above 500 cells/mm(3) were assessed. Non-AIDS severe events were defined as a first admission to the hospital due to non-AIDS-defining malignancies, cardiovascular, neuropsychiatric, liver-related, or end-stage renal disease events. Potential determinants of non-AIDS/death events were studied using Cox regression models. Eighty-five non-AIDS/death events occurred during 6,062 persons-years of follow-up (PYFU) with a CIR of 1.4 per 100 PYFU. Factors associated with non-AIDS/death event were age (HR 3.4; 95% CI: 1.6-6.9), nadir CD4 below 350 cells/mm(3) (HR 2.5; 95% CI: 1.4-4.6), and a last determination of viral load above the median (HR 1.9; 95% CI: 1.0-3.3). The CIR of non-AIDS/death events was 2.1 and 1.8 per 100 PYFU before and after cART in patients who started cART (n = 446). A reduction of CIR of non-AIDS events after cART initiation was observed only in patients with a nadir of CD4 above 350 cells/mm(3) (2.5 vs. 0.6 per 100 PYFU, p = 0.004, and remained stable after cART in patients with a median nadir of CD4 below 350 cells/mm(3). CIR was similar in elite, viremic, and noncontrollers (1.1, 1.0, and 1.5 per 100 PYFU, respectively, p = 0.25). Reduction of CIR of non-AIDS events after cART initiation depends on nadir CD4 T cell count. Most of the controllers patients had a CIR similar to noncontrollers. These data support the early initiation of cART in HIV-infected patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available