Journal
AIDS RESEARCH AND HUMAN RETROVIRUSES
Volume 28, Issue 1, Pages 54-75Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2011.0230
Keywords
-
Categories
Funding
- NIH
- National Cancer Institute
- Center for Cancer Research
- Intramural AIDS Targeted Antiviral Program
Ask authors/readers for more resources
The Gag proteins of HIV-1 are central players in virus particle assembly, release, and maturation, and also function in the establishment of a productive infection. Despite their importance throughout the replication cycle, there are currently no approved antiretroviral therapies that target the Gag precursor protein or any of the mature Gag proteins. Recent progress in understanding the structural and cell biology of HIV-1 Gag function has revealed a number of potential Gag-related targets for possible therapeutic intervention. In this review, we summarize our current understanding of HIV-1 Gag and suggest some approaches for the development of novel antiretroviral agents that target Gag.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available