Journal
AIDS RESEARCH AND HUMAN RETROVIRUSES
Volume 27, Issue 9, Pages 1005-1012Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2010.0227
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Funding
- Doris Duke Charitable Foundation
- Wellcome Trust
- Bristol Myers Squibb Secure the Future [RES116/01]
- South African DST/NRF
- MRC [G0500384] Funding Source: UKRI
- Medical Research Council [G0500384] Funding Source: researchfish
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Pediatric HIV-1 infection is characterized by rapid disease progression and without antiretroviral therapy (ART), more than 50% of infected children die by the age of 2 years. However, a small subset of infected children progresses slowly to disease in the absence of ART. This study aimed to identify functional characteristics of HIV-1-specific T cell responses that distinguish children with rapid and slow disease progression. Fifteen perinatally HIV-infected children (eight rapid and seven slow progressors) were longitudinally studied to monitor T cell polyfunctionality. HIV-1-specific interferon (IFN)-gamma(+) CD8(+) T cell responses gradually increased over time but did not differ between slow and rapid progressors. However, polyfunctional HIV-1-specific CD8(+) T cell responses, as assessed by the expression of four functions (IFN-gamma, CD107a, TNF-alpha, MIP-1 beta), were higher in slow compared to rapid progressors (p = 0.05) early in infection, and was associated with slower subsequent disease progression. These data suggest that the quality of the HIV-specific CD8(+) T cell response is associated with the control of disease in children as has been shown in adult infection.
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