Journal
AIDS RESEARCH AND HUMAN RETROVIRUSES
Volume 27, Issue 2, Pages 183-186Publisher
MARY ANN LIEBERT INC
DOI: 10.1089/aid.2010.0144
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Funding
- NIH [R01 AI080328]
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Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of <50 copies/ml without antiretroviral therapy. While HLA-B*57 and B*5801 alleles are overrepresented in ES, many HLA-B*57/B*5801 patients become chronic progressors (CP). We show here that HIV-1 infection results in similar levels of downregulation of HLA-B*57 and HLA-B*5801 molecules on primary CD4(+) T cells from ES and CP. Thus, differences in HIV-1-mediated downregulation of HLA-B*57/B*5801 molecules do not distinguish ES from CP.
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