Journal
AIDS RESEARCH AND HUMAN RETROVIRUSES
Volume 25, Issue 11, Pages 1117-1121Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2008.0282
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Funding
- National Institutes of Health (National Institute of Allergy and Infectious Diseases) [AI67136]
- National Institutes of Health (Einstein-Montefiore Center for AIDS Research) [AI51519]
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To delineate the mechanistic basis for the epidemiological association between methamphetamine use and accelerated progression to AIDS, we evaluated the direct in vitro and in vivo effects of methamphetamine on HIV-1 replication. Methamphetamine administration significantly increased HIV-1 production by both HIV-infected monocytes and CD4 T lymphocytes in vitro. In addition, in vivo methamphetamine treatment increased HIV production and viremia in mice transgenic for a replication-competent HIV provirus and human cyclinT1. Methamphetamine activated transcription of the HIV long terminal repeat (LTR) regulatory region, was associated with nuclear translocation of NF-kappa B. Our results provide further insights into the mechanisms by which methamphetamine accelerates disease course in HIV-infected individuals.
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