Journal
AIDS PATIENT CARE AND STDS
Volume 27, Issue 1, Pages 5-16Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/apc.2012.0329
Keywords
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Funding
- National Institutes of Health [R01-MH73419, T32-DA31098, P30-MH62512, T35-AG026757, L30-DA034362]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH073419, P30MH062512, R25MH071544] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R21NS083415] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [T35AG026757] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [T32DA031098] Funding Source: NIH RePORTER
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This study sought to determine the synergistic effects of age and HIV infection on medical co-morbidity burden, along with its clinical correlates and impact on health-related quality of life (HRQoL) across the lifespan in HIV. Participants included 262 individuals across four groups stratified by age (<= 40 and 50 years) and HIV serostatus. Medical co-morbidity burden was assessed using a modified version of the Charlson Co-morbidity Index (CCI). Multiple regression accounting for potentially confounding demographic, psychiatric, and medical factors revealed an interaction between age and HIV infection on the CCI, with the highest medical co-morbidity burden in the older HIV + cohort. Nearly half of the older HIV + group had at least one major medical co-morbidity, with the most prevalent being diabetes (17.8%), syndromic neurocognitive impairment (15.4%), and malignancy (12.2%). Affective distress and detectable plasma viral load were significantly associated with the CCI in the younger and older HIV-infected groups, respectively. Greater co-morbidity burden was uniquely associated with lower physical HRQoL across the lifespan. These findings highlight the prevalence and clinical impact of co-morbidities in older HIV-infected adults and underscore the importance of early detection and treatment efforts that might enhance HIV disease outcomes.
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