Journal
AIDS PATIENT CARE AND STDS
Volume 25, Issue 1, Pages 13-20Publisher
MARY ANN LIEBERT INC
DOI: 10.1089/apc.2010.0242
Keywords
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Funding
- National Institutes of Health (NIH) [K23AG024896, U01AA13566, R01HL090342, R01MH058984]
- University of Maryland Claude D. Pepper Older Americans Independence Center [P60AG 028747]
- Department of Veterans Affairs Baltimore Geriatric Research, Clinical and Education Center
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL090342] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH058984] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [K23AG024896, P30AG028747] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [U01AA013566] Funding Source: NIH RePORTER
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HIV clinical care now involves prevention and treatment of age-associated comorbidity. Although physical function is an established correlate to comorbidity in older adults without HIV infection, its role in aging of HIV-infected adults is not well understood. To investigate this question we conducted cross-sectional analyses including linear regression models of physical function in 3227 HIV-infected and 3240 uninfected patients enrolled 2002-2006 in the Veterans Aging Cohort Study-8-site (VACS-8). Baseline self-reported physical function correlated with the Short Form-12 physical subscale (rho = 0.74, p < 0.001), and predicted survival. Across the age groups decline in physical function per year was greater in HIV-infected patients (beta(coef) -0.25, p < 0.001) compared to uninfected patients (beta(coef) -0.08, p = 0.03). This difference, although statistically significant (p < 0.01), was small. Function in the average 50-year old HIV-infected subject was equivalent to the average 51.5-year-old uninfected subject. History of cardiovascular disease was a significant predictor of poor function, but the effect was similar across groups. Chronic pulmonary disease had a differential effect on function by HIV status (Delta beta(coef) -3.5, p = 0.03). A 50-year-old HIV-infected subject with chronic pulmonary disease had the equivalent level of function as a 68.1-year-old uninfected subject with chronic pulmonary disease. We conclude that age-associated comorbidity affects physical function in HIV-infected patients, and may modify the effect of aging. Longitudinal research with markers of disease severity is needed to investigate loss of physical function with aging, and to develop age-specific HIV care guidelines.
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