Journal
AIDS
Volume 28, Issue 18, Pages 2781-2786Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0000000000000489
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Funding
- Canadian Institutes of Health Research Funding Source: Medline
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Antibody-dependent activation of natural killer (NK) cells might facilitate protective outcomes in the context of HIV exposure or infection. Antibody-dependent activation is heightened in NK cells educated by interactions between killer immunoglobulin-like receptors (KIRs) and their major histocompatibility complex class I ligands during ontogeny. Differentiated NK cells, defined as CD57 R, also exhibit enhanced antibody-dependent responsiveness. Although KIRs are more frequently expressed on CD57 R NK cells, the presented data suggest education and differentiation make independent contributions to NK cell anti-HIV envelope antibody-dependent activation.
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