Journal
AIDS
Volume 28, Issue 15, Pages 2319-2322Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0000000000000419
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Funding
- Swedish International Developing Agency
- CHAIN FP7 EU
- Swedish Civil Contingencies Agency [SWE-2009-151]
- Swedish Research Council [521-2012-3476, 2007-7092]
- National Institute of Mental Health (NIMH) (Bethesda, Maryland, USA) [R01MH067513]
- National Institute of Health, USA (NIH) [1R01MH083579]
- National Institute of Mental Health [R01MH067513]
- National Institute of Health [1R01MH083579]
- Wellcome Trust/DBT India Alliance grant
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A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratio=17.1, P<0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated in HIV-1C dominating regions wherein the use of protease inhibitor drugs are being scaled up.
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