Journal
IMMUNOTHERAPY
Volume 1, Issue 4, Pages 623-630Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/IMT.09.36
Keywords
cancer; chimeric receptor; cytokine transgene; electroporation; gene modification; natural killer cell; redirection; retroviral vector; transduction
Categories
Funding
- NHMRC
- Cancer Council of Victoria
- National Health & Medical Research Council of Australia
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Immunotherapy of cancer is a rapidly developing field; one such development is the manipulation and use of natural killer (NK) cells. These cells with 'killer instincts' are an attractive cell to utilize, as they are directly reactive toward tumor and could potentially activate the endogenous adaptive immune system. Their employment in adoptive cell transfer treatments has yielded important results and discoveries, although effective antitumor responses are limited. To address these limitations, NK cells are the target of a new generation of immunotherapy involving gene transfer. The gene modification of immune cells is a relatively recent technique and some groups have targeted NK cells for gene modification to improve their antitumor efficacy. This review will investigate studies describing the gene modification of NK cells and their encouraging antitumor effects.
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