Assessment of Lipid Lowering Effect of Sida rhomboidea.Roxb Methanolic Extract in Experimentally Induced Hyperlipidemia

This inventory scrutinizes the effect of methanolic extract of Sida rhomboidea.Roxb (SR) on high fat diet-induced hyperlipidemia in male Charles foster rats. The changes in body weight, food and water intake, feed efficiency ratio and whole weight of liver and epididymal fat pad were recorded in both control and experimental groups. In addition to the above parameters, the changes in plasma lipid profile, hepatic lipid profile, fecal total lipids (TL), total cholesterol (TC), triglycerides (TG), cholic acid ( CA) and deoxycholic acid (DCA) and activity levels of plasma SGOT and SGPT were also assessed in both control and experimental groups. Plasma TC, TG, low density lipoproteins (LDL), very low density lipoproteins (VLDL) and free fatty acids (FFA) levels were decreased along with significantly increased plasma HDL levels. Hepatic TL, TC, TG were significantly decreased in HL+SR400 group, whereas fecal TL, TC, TG, CA and DCA contents were higher after feeding SR to hyperlipidemic rats, probably due to reduced intestinal absorption and effective elimination of TC, TG and bile acids through feaces. The results obtained with methanolic extract of SR are in accordance with our previous study using crude extract. Hence, this study further adds to the existing information that the polar fraction of SR is equally potent as the crude extract. This report provides an ideal platform for the isolation, purification and characterization of known bioactive/novel compounds present in the polar fraction of SR.