Journal
AIDS
Volume 26, Issue 9, Pages 1177-1180Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0b013e3283543e0e
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Funding
- Margaret E. Early Trust
- National Institute of Health (NCI) [U01-AI35040, R01-CA57152, P30-AI28697]
- California HIV/AIDS Research Program [D08-LA-311]
- James B. Pendleton Charitable Trust
- McCarthy Family Foundation
- NIH [AI-028697: UCLA]
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We show that microRNA-21 is significantly elevated in peripheral B cells of HIV-infected individuals who go on to develop AIDS-related non-Hodgkin lymphoma (n=13, <3 years prior to diagnosis) when compared with HIV-negative (n=18) or HIV-positive controls (n=21) (P<0.01). Moreover, miR-21 is overexpressed in activated B cells and can be induced by interleukin 4 alone, or with CD40 or immunoglobulin M co-stimulation, and lipopolysaccharides, suggesting that miR-21 may help maintain B-cell hyperactivation, contributing to lymphomagenesis.
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