Journal
AIDS
Volume 25, Issue 5, Pages 715-717Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0b013e328343c186
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Funding
- Doris Duke Charitable Foundation
- Phillip T. and Susan M. Ragon Foundation
- Bill and Melinda Gates Foundation
- National Health and Medical Research Council of Australia [519578]
- Ragon Fellowship
- National Cancer Institute, National Institutes of Health [HHSN261200800001E]
- [RO1 216753]
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Recognition of HIV-1 ssRNA by Toll-like receptor 7 induces the production of the pro-inflammatory cytokines that may contribute to the systemic immune activation associated with HIV-1 disease progression. Here, we describe a novel association between polymorphisms in interferon regulatory factor 7 (IRF7), a master regulator of interferon-alpha (IFN-alpha), and the ability of plasmacytoid dendritic cells to produce IFN-alpha in response to HIV-1. IRF7 polymorphisms may, therefore, affect the ability of individuals to respond to HIV-1 and modulate HIV-1 disease progression.
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