Journal
AIDS
Volume 25, Issue 9, Pages 1235-1237Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0b013e3283474155
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Some previously immunodeficient HIV patients responding to antiretroviral therapy display poor recovery of CD4(+) T cells. Evaluation of the contribution of thymic function requires sensitive detection and quantitation of metabolically active thymic tissue. We describe patients with low but detectable thymopoiesis assessed as circulating CD4(+) naive T cells expressing CD31. High-resolution computed tomography and PET scans found no residual thymic tissue even though metabolic activity was demonstrable by PET in lymph nodes.
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