Journal
AIDS
Volume 23, Issue 15, Pages 2047-2050Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0b013e328330342c
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Funding
- amfAR research grant [106867-42-RFRL]
- National Health and Medical Research Council (NHMRC [478100]
- NHMRC Program Grant [358399]
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We investigated the ability of several novel class I histone deacetylase inhibitors to activate HIV-1 transcription in latently infected cell lines. Oxamflatin, metacept-1 and metacept-3 induced high levels of HIV-1 transcription in latently infected T cell and monocytic cells lines, were potent inhibitors of histone deacetylase activity and caused preferential cell death in transcriptionally active cells. Although these compounds had potent in-vitro activity, their cytotoxicity may limit their use in patients.
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