Journal
JOURNAL OF CHEMICAL SCIENCES
Volume 121, Issue 4, Pages 397-405Publisher
INDIAN ACAD SCIENCES
DOI: 10.1007/s12039-009-0046-3
Keywords
Ruthenium(II) complex; DNA-binding; photocleavage
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Funding
- Provincial Natural Science Fund of Hunan [09JJ6019]
- Scientific Research Foundation of Hunan Provincial Education Department [08B086]
- China Postdoctoral Science Foundation [20080440986]
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A novel polypyridyl ligand phenyl-(4,5,9,14-tetraaza-benzo[b]triphenylen-1,1-yl)-methanone (PTBM) and its complexes [Ru(phen)(2)(PTBM)](2+) (1) (phen = 1,10-phenanthroline) and [Ru(bpy)(2) (PTBM)](2+) (2) (bpy = 2,2'-bipyridine) have been synthesized and characterized by elemental analysis, mass spectroscopy, and H-1 NMR. The DNA-binding properties of the two complexes were investigated by spectroscopic and viscosity measurements. The results indicate that both complexes bind to DNA via an intercalative mode and the DNA-binding affinity of complex 1 is greater than that of complex 2. When irradiated at 365 nm, complex 1 was found to be a more-effective DNA-cleaving agent than complex 2.
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