Journal
AIDS
Volume 22, Issue 16, Pages 2214-2217Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0b013e328314b5df
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Funding
- International AIDS Vaccine Initiative
- Wellcome Trust
- Oxford Glycobiology Endowment
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Only one broadly neutralizing anti-HIV antibody, 2G12, recognises the envelope sugars of HIV. In the present study, we show that 2G12 also recognises Candida albicans and Candida tropicalis with high affinity (11 nmol/1) through a carbohydratedependent interaction (50% inhibitory concentration for D-fiructose, 12 mmol/1). This is the first report of a neutralizing HIV antibody displaying cross-reactivity with another pathogen, revealing that the carbohydrate neutralization determinant of HIV, defined by 2G12, is more widespread amongst immunogenic, microbial surfaces than previously recognized
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