Journal
AICHE JOURNAL
Volume 61, Issue 3, Pages 756-768Publisher
WILEY
DOI: 10.1002/aic.14692
Keywords
fluid bed; coating; cycle time; residence time distribution; positron emission particle tracking
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Funding
- PowTech Marie Curie Initial Training Network [EU FP7-PEOPLE-2010-ITN-264722]
- AstraZeneca RD
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Particle cycle and residence time distributions are critical factors in determining the coating quality in the Wurster process. Positron emission particle tracking experiments are performed to determine the cycle and residence times of particles in different regions of a Wurster fluid bed. The results show that particles tend to recirculate in and sneak out below from the Wurster tube. The experiments also show that a larger batch size leads to a shorter cycle time and a narrower cycle time distribution (CTD). It is possible to avoid recirculations and obtain a shorter cycle time and a narrower CTD by selecting the operating conditions appropriately or via equipment design. Experiments using binary mixtures of particles with a diameter ratio of 1.5 show that large particles have a longer cycle time than small particles and that the cycle time is shorter for mixtures with approximately equal amounts of small and large particles. (c) 2014 American Institute of Chemical Engineers AIChE J, 61: 756-768, 2015
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