Journal
NATURE REVIEWS IMMUNOLOGY
Volume 9, Issue 8, Pages 543-555Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2602
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Funding
- Medical Research Council
- Biotechnology and Biological Science Research Council
- Wellcome Trust
- Wolfson Royal Society Research Merit Award
- BBSRC [BB/D011663/1] Funding Source: UKRI
- MRC [G0500563] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D011663/1] Funding Source: researchfish
- Medical Research Council [G0500563] Funding Source: researchfish
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Communication across intercellular contacts is central to establishing appropriate innate and adaptive immune responses. Recent imaging of lymphocyte interactions suggests that a complex orchestration of cell-cell contact times is a key correlate to establishing appropriate immune responses. Here I review the molecular and cellular processes that influence the duration of intercellular contacts, including integrin activation and dynamic changes in membrane morphology. I discuss how these processes can be regulated, for example, by the balance of activating and inhibitory receptor signals, and how they can establish the appropriate outcome for individual cell-cell interactions.
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