Journal
TRANSITION METAL CHEMISTRY
Volume 34, Issue 5, Pages 475-481Publisher
SPRINGER
DOI: 10.1007/s11243-009-9219-7
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Funding
- National Natural Science Foundation of China [20771063]
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Three new reduced amino-acid Schiff base complexes, [Co(HL)(2)(H2O)(2)] center dot A 4H(2)O (1), [Cu(HL)(2)(H2O)(2)] center dot A 2H(2)O (2), and [Cd(HL)(2)(H2O)(3)] center dot A 2H(2)O (3), where H2L is the reduced Schiff-base ligand derived from the condensation of N-(4-hydroxybenzaldehyde) with L-glycine, have been synthesized and characterized by physico-chemical and spectroscopic methods. In these complexes, the two bidentate monoanionic Schiff base ligands coordinate the metal center through the secondary amine N atom and the carboxylate O atom. Water ligands complete a distorted octahedral (1, 2) or a pentagonal bipyramidal coordination geometry (3) around each metal center. The binding interactions of the complexes with CT-DNA have been investigated by UV-visible spectrophotometry and fluorescence quenching methods. The results show that these complexes bind to CT-DNA with an intercalative mode. In addition, DNA cleavage experiments have been also investigated by agarose gel electrophoresis. Complexes 1-3 show oxidative DNA cleavage activity in the presence of H2O2/sodium ascorbate and the reactive oxygen species responsible for the DNA cleavage is most likely singlet oxygen.
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