Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 45, Issue 2, Pages 99-105Publisher
ELSEVIER
DOI: 10.1016/j.ijantimicag.2014.10.003
Keywords
Capnocytophaga; Prevotella; cfxA; Biofilm; Integron; beta-Lactamase
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Many beta-lactamases have been described in various Gram-negative bacilli (Capnocytophaga, Prevotella, Fusobacterium, etc.) of the oral cavity, belonging to class A of the Ambler classification (CepA, CblA, CfxA, CSP-1 and TEM), class B (CfiA) or class D in Fusobacterium nucleatum (FUS-1). The minimum inhibitory concentrations of beta-lactams are variable and this variation is often related to the presence of plasmids or other mobile genetic elements (MGEs) that modulate the expression of resistance genes. DNA persistence and bacterial promiscuity in oral biofilms also contribute to genetic transformation and conjugation in this particular microcosm. Overexpression of efflux pumps is facilitated because the encoding genes are located on MGEs, in some multidrug-resistant clinical isolates, similar to conjugative transposons harbouring genes encoding beta-lactamases. All these facts lead us to consider the oral cavity as an important reservoir of beta-lactam resistance genes and a privileged place for genetic exchange, especially in commensal strictly anaerobic Gram-negative bacilli. (C) 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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