Journal
AGING-US
Volume 4, Issue 3, Pages 146-158Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100445
Keywords
Resveratrol; SIRT1; sirtuins; calorie restriction; aging; metabolic diseases
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The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms. Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation.
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