Journal
AGING-US
Volume 4, Issue 1, Pages 13-27Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100424
Keywords
DGAT1; adipose tissue; longevity; triglycerides; calorie restriction
Categories
Funding
- Elison Medical Foundation
- NIH [RO1-DK056084]
- NIH/NCRR [CO6 RR18928]
- J. David Gladstone Institutes
- NATIONAL CENTER FOR RESEARCH RESOURCES [C06RR018928] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK056084] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Calorie restriction results in leanness, which is linked to metabolic conditions that favor longevity. We show here that deficiency of the triglyceride synthesis enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), which promotes leanness, also extends longevity without limiting food intake. Female DGAT1-deficient mice were protected from age-related increases in body fat, tissue triglycerides, and inflammation in white adipose tissue. This protection was accompanied by increased mean and maximal life spans of (similar to)25% and (similar to)10%, respectively. Middle-aged Dgat1(-/-) mice exhibited several features associated with longevity, including decreased levels of circulating insulin growth factor 1 (IGF1) and reduced fecundity. Thus, deletion of DGAT1 in mice provides a model of leanness and extended lifespan that is independent of calorie restriction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available