Journal
AGING-US
Volume 3, Issue 4, Pages 430-437Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100312
Keywords
aging; sirtuins; SIRT1; skeletal muscle; differentiation; nutrients
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Skeletal muscle aging is associated with increased inflammation and oxidative stress, a decrease in the ability to rebuild muscle after injury and in response to exercise. In this perspective, we discuss the mechanisms regulating Sirt1 activity and expression in skeletal muscles, emphasizing their implications in muscle physiology and the impairment of muscle function with age.
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