Journal
AGING-US
Volume 3, Issue 5, Pages 543-547Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100326
Keywords
aging; metabolism; longevity; sirtuins; PARP
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Funding
- Ecole Polytechnique Federale de Lausanne
- Swiss National Science Foundation
- NIH [DK59820]
- European Research Council [ERC-2008-AdG23118]
- Velux foundation
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Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators.
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