Journal
AGING-US
Volume 3, Issue 5, Pages 479-493Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100323
Keywords
circadian rhythms; clock; Bmal1; period; cryptochrome; cancer; aging
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Funding
- National Institutes of Neurological Diseases and Stroke, National Institutes of Health [R01 NS056125]
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The circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology in virtually all cells. Disruption of the genes necessary for the circadian clock to function has diverse effects, including aging-related phenotypes. Some circadian clock genes have been described as tumor suppressors, while other genes have less clear functions in aging and cancer. In this Review, we highlight a recent study [Dubrovsky et al., Aging 2: 936-944, 2010] and discuss the much larger field examining the relationship between circadian clock genes, circadian rhythmicity, aging-related phenotypes, and cancer.
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