Journal
AGING-US
Volume 2, Issue 9, Pages 535-537Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100202
Keywords
Aging; cancer; DNA damage response; nutlin; p21; rapamycin
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The full spectrum of activities of the tumor suppressor p53 (TP53) has not been completely elucidated yet. Recently, it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quiescence or irreversible senescence, thereby adding yet another level of complexity to the signaling network that emanate from TP53.
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