Journal
AGING-US
Volume 2, Issue 12, Pages 1017-1022Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100262
Keywords
progeria; cancer; growth hormone; insulin-like growth factor; longevity
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Funding
- Ministerio de Ciencia e Innovacion-Spain
- Fundacion M. Botin
- European Union
- Obra Social Cajastur and Accion Transversal del Cancer-RTICC
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We have recently reported that progeroid Zmpste24(-/-) mice, which exhibit multiple defects that phenocopy Hutchinson-Gilford progeria syndrome, show a profound dysregulation of somatotropic axis, mainly characterized by the occurrence of very high circulating levels of growth hormone (GH) and a drastic reduction in insulin-like growth factor-1 (IGF-1). We have also shown that restoration of the proper GH/IGF-1 balance in Zmpste24(-/-) mice by treatment with recombinant IGF-1 delays the onset of many progeroid features in these animals and significantly extends their lifespan. Here, we summarize these observations and discuss the importance of GH/IGF-1 balance in longevity as well as its modulation as a putative therapeutic strategy for the treatment of human progeroid syndromes.
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