Journal
AGING-US
Volume 1, Issue 7, Pages 586-597Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100070
Keywords
ageing; TOR; protein synthesis; autophagy; rapamycin
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Funding
- Medical Research Council (MRC)
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Gerald Kerkut Trust
- AstraZeneca
- Wellcome Trust
- British Heart Foundation
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The molecular and cellular mechanisms that regulate ageing are currently under scrutiny because ageing is linked to many human diseases. The nutrient sensing TOR pathway is emerging as a key regulator of ageing. TOR signaling is complex affecting several crucial cellular functions and two such functions, which show clear effects on ageing, are protein synthesis and autophagy. In this article we discuss the relative importance of both these processes in ageing, identify how TOR regulates translation and autophagy and speculate on links between the TOR signaling network and ageing pathways.
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