Journal
AGING-US
Volume 1, Issue 4, Pages 357-362Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100040
Keywords
aging; growth; rapamycin; TOR; mitochondria
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Funding
- Swiss National Science Foundation
- Canton of Basel
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It is commonly assumed that growth and aging are somehow linked, but the nature of this link has been elusive. Here we review the aging process as a continuation of TOR-driven growth. TOR is absolutely essential for developmental growth, but upon completion of development it causes aging and age-related diseases. Thus, the nutrient-sensing and growth-promoting TOR signaling pathway may provide a molecular link between growth and aging that is universal from yeast to human.
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