Journal
AGING MALE
Volume 22, Issue 4, Pages 241-249Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13685538.2018.1506918
Keywords
Testosterone; endothelial dysfunction; type 2 diabetes mellitus; endothelium
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Funding
- Russian Science Foundation [14-25-00052]
- Russian Science Foundation [14-25-00052] Funding Source: Russian Science Foundation
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Effects of testosterone (T) on the cardiovascular system of men remain controversial. The impact of T-replacement therapy (TRT) in men with functional hypogonadism and type 2 diabetes mellitus (T2DM) has to be elucidated. This study included 80 men (mean age 51.5???6.3?years) with newly diagnosed T2DM (according to ADA criteria) and functional hypogonadism (according to EAU criteria). Randomization: Group1 (n?=?40): TRT using 1%-transdermal T-gel (50?mg/day), Group2 (n?=?40) no TRT (controls). Dietary treatment applied to both. Parameters at baseline/after 9?months: anthropometric parameters, lipids and indicators of carbohydrate metabolism (fasting glucose, insulin, HbA1c, HOMA-IR), markers of adipose tissue and EnD (leptin, resistin, p- and e-selectin, ICAM- 1, VCAM- 1 and CRP). ANCOVA for repeated measurements revealed TRT to cause a significant decrease in waist circumference (WC), HOMA-IR and HbA1c vs controls (p?
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