Journal
AGING CELL
Volume 12, Issue 4, Pages 615-621Publisher
WILEY
DOI: 10.1111/acel.12086
Keywords
human; leukocytes; longitudinal; Southern blots; telomeres
Categories
Funding
- NIH [AG16592, AG030678]
- US-Israel Binational Science Foundation
- Israel Science Foundation
- Fondation pour la Recherche Medicale [FRM DCV-20070409250]
- Caisse Nationale d'Assurance Maladie
- Agence Nationale de la Recherche [ANR 09-GENO-010-01]
- Plan Pluri-Formation (French Ministry of Research)
- National Program for Research Infrastructure
- VELUX foundation
Ask authors/readers for more resources
Short leukocyte telomere length (LTL) is associated with atherosclerosis in adults and diminished survival in the elderly. LTL dynamics are defined by LTL at birth, which is highly variable, and its age-dependent attrition thereafter, which is rapid during the first 20years of life. We examined whether age-dependent LTL attrition during adulthood can substantially affect individuals' LTL ranking (e.g., longer or shorter LTL) in relation to their peers. We measured LTL in samples donated 12years apart on average by 1156 participants in four longitudinal studies. We observed correlations of 0.91-0.96 between baseline and follow-up LTLs. Ranking individuals by deciles revealed that 94.1% (95% confidence interval of 92.6-95.4%) showed no rank change or a 1 decile change over time. We conclude that in adults, LTL is virtually anchored to a given rank with the passage of time. Accordingly, the links of LTL with atherosclerosis and longevity appear to be established early in life. It is unlikely that lifestyle and its modification during adulthood exert a major impact on LTL ranking.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available