Journal
AGING CELL
Volume 12, Issue 3, Pages 525-530Publisher
WILEY
DOI: 10.1111/acel.12065
Keywords
aging; anti-aging; heterochronic studies; longevity; mice; parabiosis
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Funding
- NIA NIH HHS [P01 AG036695] Funding Source: Medline
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Pairing two animals in parabiosis to test for systemic or circulatory factors from one animal affecting the other animal has been used in scientific studies for at least 150years. These studies have led to advances in fields as diverse as endocrinology, immunology, and oncology. A variation on the technique, heterochronic parabiosis, whereby two animals of different ages are joined to test for systemic regulators of aspects of aging or age-related diseases also has almost a century-long scientific history. In this review, we focus on the history of heterochronic parabiosis, methodological considerations and caveats, and the major advances that have emerged from those studies, including recent advances in our understanding of stem cell aging.
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