Related references
Note: Only part of the references are listed.mTOR in aging, metabolism, and cancer
Marion Cornu et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2013)
Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization
Stella Tommasi et al.
NUCLEIC ACIDS RESEARCH (2013)
Increased age of transformed mouse neural progenitor/stem cells recapitulates age-dependent clinical features of human glioma malignancy
Andrei M. Mikheev et al.
AGING CELL (2012)
HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway
L. Qiang et al.
CELL DEATH AND DIFFERENTIATION (2012)
REST regulates the pool size of the different neural lineages by restricting the generation of neurons and oligodendrocytes from neural stem/progenitor cells
Matthew V. Covey et al.
DEVELOPMENT (2012)
Brain energy metabolism and blood flow differences in healthy aging
Joel Aanerud et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)
IDH1 mutations inhibit multiple α-ketoglutarate-dependent dioxygenase activities in astroglioma
Ying Liu et al.
JOURNAL OF NEURO-ONCOLOGY (2012)
Mammalian Target of Rapamycin Signaling Is a Key Regulator of the Transit-Amplifying Progenitor Pool in the Adult and Aging Forebrain
Grigorios N. Paliouras et al.
JOURNAL OF NEUROSCIENCE (2012)
Conditional Astroglial Rictor Overexpression Induces Malignant Glioma in Mice
Tariq Bashir et al.
PLOS ONE (2012)
Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice
Dinorah Friedmann-Morvinski et al.
SCIENCE (2012)
REST Regulates Oncogenic Properties of Glioblastoma Stem Cells
Mohamed M. Kamal et al.
STEM CELLS (2012)
Expression of stem cell marker and receptor kinase genes in glioblastoma tissue quantified by real-time RT-PCR
Koji Yoshimoto et al.
BRAIN TUMOR PATHOLOGY (2011)
Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3
Olga A. Guryanova et al.
CANCER CELL (2011)
Cooperativity within and among Pten, p53, and Rb Pathways Induces High-Grade Astrocytoma in Adult Brain
Lionel M. L. Chow et al.
CANCER CELL (2011)
HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells
Julie Mathieu et al.
CANCER RESEARCH (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Acidic stress promotes a glioma stem cell phenotype
A. B. Hjelmeland et al.
CELL DEATH AND DIFFERENTIATION (2011)
Glycolysis inhibition by 2-deoxy-d-glucose reverts the metastatic phenotype in vitro and in vivo
Joseph L. Sottnik et al.
CLINICAL & EXPERIMENTAL METASTASIS (2011)
TOR on the brain
Michael G. Garelick et al.
EXPERIMENTAL GERONTOLOGY (2011)
Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis
Masahiro Okamoto et al.
FASEB JOURNAL (2011)
Microglia/Macrophages Promote Glioma Progression
Haiyan Zhai et al.
GLIA (2011)
Aging Neural Progenitor Cells Have Decreased Mitochondrial Content and Lower Oxidative Metabolism
Elizabeth A. Stoll et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Pathway Analysis of Glioblastoma Tissue after Preoperative Treatment with the EGFR Tyrosine Kinase Inhibitor Gefitinib-A Phase II Trial
Monika E. Hegi et al.
MOLECULAR CANCER THERAPEUTICS (2011)
Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis
Alyssa L. Kennedy et al.
MOLECULAR CELL (2011)
Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis
Max R. Banko et al.
MOLECULAR CELL (2011)
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
Saul A. Villeda et al.
NATURE (2011)
The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence
Wanyu L. Lambiv et al.
NEURO-ONCOLOGY (2011)
Cerebral microvascular pathology in ageing and neurodegeneration
W. R. Brown et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2011)
Enhanced anti-glioblastoma activity of microglia by AAV2-mediated IL-12 through TRAIL and phagocytosis in vitro
Tsung-Lang Chiu et al.
ONCOLOGY REPORTS (2011)
Energy metabolism in adult neural stem cell fate
Victoria A. Rafalski et al.
PROGRESS IN NEUROBIOLOGY (2011)
Increased Re-Entry into Cell Cycle Mitigates Age-Related Neurogenic Decline in the Murine Subventricular Zone
Elizabeth A. Stoll et al.
STEM CELLS (2011)
Molecular Classification of Low-Grade Diffuse Gliomas
Young Ho Kim et al.
AMERICAN JOURNAL OF PATHOLOGY (2010)
Potential therapeutic implications of cancer stem cells in glioblastoma
Lin Cheng et al.
BIOCHEMICAL PHARMACOLOGY (2010)
Integrin Alpha 6 Regulates Glioblastoma Stem Cells
Justin D. Lathia et al.
CELL STEM CELL (2010)
CX3CR1 promotes recruitment of human glioma-infiltrating microglia/macrophages (GIMs)
Janka Held-Feindt et al.
EXPERIMENTAL CELL RESEARCH (2010)
Cross-species genomics matches driver mutations and cell compartments to model ependymoma
Robert A. Johnson et al.
NATURE (2010)
mTOR signaling in glioblastoma: lessons learned from bench to bedside
David Akhavan et al.
NEURO-ONCOLOGY (2010)
Prevalence estimates for primary brain tumors in the United States by age, gender, behavior, and histology
Kimberly R. Porter et al.
NEURO-ONCOLOGY (2010)
A mathematical framework to determine the temporal sequence of somatic genetic events in cancer
Camille Stephan-Otto Attolini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Cdk2 Is Required for p53-Independent G2/M Checkpoint Control
Jon H. Chung et al.
PLOS GENETICS (2010)
A syngeneic glioma model to assess the impact of neural progenitor target cell age on tumor malignancy
Andrei M. Mikheev et al.
AGING CELL (2009)
Expression of Mutant p53 Proteins Implicates a Lineage Relationship between Neural Stem Cells and Malignant Astrocytic Glioma in a Murine Model
Yuan Wang et al.
CANCER CELL (2009)
Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Models
Sheila Alcantara Llaguno et al.
CANCER CELL (2009)
Microenvironmental Independence Associated with Tumor Progression
Alexander R. A. Anderson et al.
CANCER RESEARCH (2009)
Mutant p53 Drives Invasion by Promoting Integrin Recycling
Patricia A. J. Muller et al.
CELL (2009)
A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis
Maddalena Adorno et al.
CELL (2009)
The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype
John M. Heddleston et al.
CELL CYCLE (2009)
p53 Acetylation Is Crucial for Its Transcription-independent Proapoptotic Functions
Hirohito Yamaguchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target
Randy L. Jensen
JOURNAL OF NEURO-ONCOLOGY (2009)
Neural Stem and Progenitor Cells Retain Their Potential for Proliferation and Differentiation into Functional Neurons Despite Lower Number in Aged Brain
Henrik Ahlenius et al.
JOURNAL OF NEUROSCIENCE (2009)
Telomere Shortening in Neural Stem Cells Disrupts Neuronal Differentiation and Neuritogenesis
Sacri R. Ferron et al.
JOURNAL OF NEUROSCIENCE (2009)
p53 Suppresses Src-Induced Podosome and Rosette Formation and Cellular Invasiveness through the Upregulation of Caldesmon
Utpal K. Mukhopadhyay et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3
Anjali Shukla et al.
NATURE CELL BIOLOGY (2009)
Advances in the genetics of glioblastoma: are we reaching critical mass?
Benjamin Purow et al.
NATURE REVIEWS NEUROLOGY (2009)
IDH1 and IDH2 Mutations in Gliomas
Hai Yan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Rapamycin Response in Tumorigenic and Non-Tumorigenic Hepatic Cell Lines
Rosa H. Jimenez et al.
PLOS ONE (2009)
Glioblastoma Subclasses Can Be Defined by Activity among Signal Transduction Pathways and Associated Genomic Alterations
Cameron Brennan et al.
PLOS ONE (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression
Jinsuke Nishino et al.
CELL (2008)
Nontelomeric TRF2-REST Interaction Modulates Neuronal Gene Silencing and Fate of Tumor and Stem Cells
Peisu Zhang et al.
CURRENT BIOLOGY (2008)
A hybrid cellular automaton model of clonal evolution in cancer: The emergence of the glycolytic phenotype
P. Gerlee et al.
JOURNAL OF THEORETICAL BIOLOGY (2008)
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
L. Chin et al.
NATURE (2008)
Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint
Edward Owusu-Ansah et al.
NATURE GENETICS (2008)
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Jean-Philippe Coppe et al.
PLOS BIOLOGY (2008)
Survivin repression by p53, Rb and E2F2 in normal human melanocytes
Deepak Raj et al.
CARCINOGENESIS (2008)
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
Ralph J. DeBerardinis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Optimal Signal Processing in Small Stochastic Biochemical Networks
Etay Ziv et al.
PLOS ONE (2007)
Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotype
Daniel A. Lim et al.
NEURO-ONCOLOGY (2007)
Genetic pathways to primary and secondary glioblastoma
Hiroko Ohgaki et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
Mutant p53: an oncogenic transcription factor
S. Strano et al.
ONCOGENE (2007)
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Shideng Bao et al.
NATURE (2006)
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Anna V. Molofsky et al.
NATURE (2006)
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
Karim Bensaad et al.
CELL (2006)
Inhibition of hypoxia inducible factor-1α (HIF-1α) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas
Randy L. Jensen et al.
JOURNAL OF NEURO-ONCOLOGY (2006)
Chronically increased transforming growth factor-β1 strongly inhibits hippocampal neurogenesis in aged mice
Marion S. Buckwalter et al.
AMERICAN JOURNAL OF PATHOLOGY (2006)
Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses
Marcela Assanah et al.
JOURNAL OF NEUROSCIENCE (2006)
p53 regulates mitochondrial respiration
Satoaki Matoba et al.
SCIENCE (2006)
'Pseudopalisading' necrosis in glioblastoma: A familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis
Yuan Rong et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2006)
Stem/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: Role of astrocytes
AK Shetty et al.
GLIA (2005)
Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas
H Ohgaki et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2005)
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
RG Jones et al.
MOLECULAR CELL (2005)
Glioblastoma-induced attraction of endogenous neural precursor cells is associated with improved survival
R Glass et al.
JOURNAL OF NEUROSCIENCE (2005)
Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice
AY Maslov et al.
JOURNAL OF NEUROSCIENCE (2004)
Isolation of cancer stem cells from adult glioblastoma multiforme
XP Yuan et al.
ONCOGENE (2004)
Accumulation of mutations and somatic selection in aging neural stem/progenitor cells
KJ Bailey et al.
AGING CELL (2004)
Identification of human brain tumour initiating cells
SK Singh et al.
NATURE (2004)
Why do cancers have high aerobic glycolysis?
RA Gatenby et al.
NATURE REVIEWS CANCER (2004)
Neurogenesis and aging: FGF-2 and HB-EGF restore neurogenesis in hippocampus and subventricular zone of aged mice
KL Jin et al.
AGING CELL (2003)
Thymic CD8(+) T cell production strongly influences tumor antigen recognition and age-dependent glioma mortality
CJ Wheeler et al.
JOURNAL OF IMMUNOLOGY (2003)
Age and radiation response in glioblastoma multiforme
FG Barker et al.
NEUROSURGERY (2001)
Preferential inactivation of the p53 tumor suppressor pathway and lack of EGFR amplification distinguish de novo high grade pediatric astrocytomas from de novo adult astrocytomas
T Sung et al.
BRAIN PATHOLOGY (2000)
Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
EC Holland et al.
NATURE GENETICS (2000)
Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects
KM Reilly et al.
NATURE GENETICS (2000)
Share Paper
