Journal
AGING CELL
Volume 11, Issue 2, Pages 360-362Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1474-9726.2011.00778.x
Keywords
Alzheimer's disease; DNA damage; Drosophila
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Funding
- Medical Research Council [G0902418] Funding Source: Medline
- Medical Research Council [G0902418] Funding Source: researchfish
- MRC [G0902418] Funding Source: UKRI
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ATM and p53, effectors of the DNA damage checkpoint, are generally considered pro-apoptotic in neurons. We show that DNA damage and checkpoint activation occurs in postmitotic neurons in animal models of tauopathy, neurodegenerative disorders that include Alzheimers disease. Surprisingly, checkpoint attenuation potently increases neurodegeneration through aberrant cell cycle re-entry of postmitotic neurons. These data suggest an unexpected neuroprotective role for the DNA damage checkpoint in tauopathies.
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