Journal
AGING CELL
Volume 11, Issue 1, Pages 178-180Publisher
WILEY
DOI: 10.1111/j.1474-9726.2011.00771.x
Keywords
lymphocytes; immunosenescence; inflammation; naive T cells; soay sheep; d T cells
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Funding
- Biotechnology and Biological Sciences Research Council [BB/H021868/1] Funding Source: Medline
- Wellcome Trust [096669, 095831] Funding Source: Medline
- BBSRC [BB/H021868/1] Funding Source: UKRI
- NERC [NE/G004854/1, NE/E01237X/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/H021868/1] Funding Source: researchfish
- Natural Environment Research Council [NE/E01237X/1, NE/G004854/1] Funding Source: researchfish
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Age-related changes in immunity are well documented in humans and laboratory mammals. Using blood samples collected from wild Soay sheep, we show that pronounced differences in T-cell subsets and inflammatory markers amongst age classes are also evident under natural conditions. These shifts parallel those observed in mammals experiencing protected environments. We found progressive declines in the proportion of naive CD4 T cells with age, a precipitous drop in d T cells after the second year of life and an increase in acute phase protein levels amongst geriatric sheep. Our findings suggest immune aging patterns observed in laboratory and domestic mammals may generalize to more complex, challenging environments and could have fitness costs under natural conditions.
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