Journal
AGING CELL
Volume 9, Issue 1, Pages 100-103Publisher
WILEY
DOI: 10.1111/j.1474-9726.2009.00537.x
Keywords
dietary restriction; Drosophila; electron transport chain; mitochondria
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Funding
- NIA NIH HHS [P30-AG028748, P30 AG028748-01, P30 AG028748] Funding Source: Medline
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P>Studies in a broad spectrum of model organisms have reported that dietary restriction (DR) is associated with an increase in mitochondrial electron transport chain (ETC) function. However, the question of whether ETC function is required for DR-mediated longevity remains controversial. Here, we report that genetic and pharmacological interventions that target mitochondrial complex V affect Drosophila lifespan in a nutrient-dependent manner. These findings support a requirement for mitochondrial complex V in DR-mediated longevity in flies.
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