Journal
AGEING RESEARCH REVIEWS
Volume 14, Issue -, Pages 31-42Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2014.01.003
Keywords
Synapse; Ageing; Postsynaptic density; Neurotransmitter vesicles; Presynaptic bouton; Dendritic spine
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Funding
- NIA/NIH
- NIDCD/NIH
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Impaired synaptic plasticity is implicated in the functional decline of the nervous system associated with ageing. Understanding the structure of ageing synapses is essential to understanding the functions of these synapses and their role in the ageing nervous system. In this review, we summarize studies on ageing synapses in vertebrates and invertebrates, focusing on changes in morphology and ultrastructure. We cover different parts of the nervous system, including the brain, the retina, the cochlea, and the neuromuscular junction. The morphological characteristics of aged synapses could shed light on the underlying molecular changes and their functional consequences. Published by Elsevier B.V.
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