Journal
AGEING RESEARCH REVIEWS
Volume 11, Issue 4, Pages 460-472Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2012.03.004
Keywords
Translational control; 3 ' UTR; Cytoplasmic polyadenylation; CPEB; Senescence; Cancer
Categories
Funding
- ICREA Funding Source: Custom
- Worldwide Cancer Research [11-0086] Funding Source: Medline
- Worldwide Cancer Research [11-0086] Funding Source: researchfish
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Cytoplasmic elongation of the poly(A) tail was originally identified as a mechanism to activate maternal mRNAs, stored as silent transcripts with short poly(A) tails, during meiotic progression. A family of RNA-binding proteins named CPEBs, which recruit the translational repression or cytoplasmic polyadenylation machineries to their target mRNAs, directly mediates cytoplasmic polyadenylation. Recent years have witnessed an explosion of studies showing that CPEBs are not only expressed in a variety of somatic tissues, but have essential functions controlling gene expression in time and space in the adult organism. These new functions of the CPEBs include regulating the balance between senescence and proliferation and its pathological manifestation, tumor development. In this review, we summarize current knowledge on the functions of the CPEB-family of proteins in the regulation of cell proliferation, their target mRNAs and the mechanism controlling their activities. (C) 2012 Published by Elsevier B.V.
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