Journal
AGEING RESEARCH REVIEWS
Volume 10, Issue 3, Pages 330-335Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2010.08.004
Keywords
Aging; B lymphocytes; Immunoglobulin class switch; Influenza vaccination
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Funding
- NIH [AG-17618, AG-23717, AG-28586]
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Both humoral and cellular immune responses are impaired in aged individuals, leading to decreased vaccine responses. Although T cell defects occur, defects in B cells play a significant role in age-related humoral immune changes. The ability to undergo class switch recombination (CSR), the enzyme for CSR, AID (activation-induced cytidine deaminase) and the transcription factor E47 are all decreased in aged stimulated B cells. We here present an overview of age-related changes in human B cell markers and functions, and also discuss some controversies in the field of B cell aging. (C) 2010 Elsevier B.V. All rights reserved.
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