Journal
AGEING RESEARCH REVIEWS
Volume 10, Issue 1, Pages 80-92Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2010.04.009
Keywords
Age; Thermal sensitivity; Perception; Temperature; Peripheral nerve system; Quantitative sensory testing
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Aging is associated with a progressive decrease in thermal perception, as revealed by increased thermal detection thresholds in the elderly. This reduction in thermosensitivity follows a distal-proximal pattern, with more pronounced decrements observed in the limbs and in the perception of warmth vs. cold. The main underlying causes of this seem to be aging of the skin and subsequent reductions in thermoreceptor density and superficial skin blood flow. However, the results from some animal studies also suggest that changes in the peripheral nerve system, particularly fiber loss and decreased conduction velocity, may also be involved. In this paper, we review age-related changes in the thermal sensitivity of humans, their underlying mechanisms, and the strengths and limitations of some of the methodologies used to assess these changes. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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