Journal
AGEING RESEARCH REVIEWS
Volume 10, Issue 1, Pages 16-25Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2009.10.005
Keywords
Ageing; Cell; Cytoskeleton; Mechanical properties; Elastic modulus
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Funding
- Belarusian Republican Foundation of Fundamental Research
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Mechanical properties are fundamental properties of the cells and tissues of living organisms. The mechanical properties of a single cell as a biocomposite are determined by the interdependent combination of cellular components mechanical properties. Quantitative estimate of the cell mechanical properties depends on a cell state, method of measurement, and used theoretical model. Predominant tendency for the majority of cells with ageing is an increase of cell stiffness and a decrease of cell ability to undergo reversible large deformations. The mechanical signal transduction in old cells becomes less effective than that in young cells, and with ageing, the cells lose the ability of the rapid functional rearrangements of cellular skeleton. The article reviews the theoretical and experimental facts touching the age-related changes of the mechanical properties of cellular components and cells in the certain systems of an organism (the blood, the vascular system, the musculoskeletal system, the lens, and the epithelium). In fact, the cell mechanical parameters (including elastic modulii) can be useful as specific markers of cell ageing. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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