Journal
AGEING RESEARCH REVIEWS
Volume 8, Issue 2, Pages 83-93Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2008.11.002
Keywords
Atherosclerosis; Endothelial progenitor cells; Reendothelialization; Neovascularization; Cell-based therapy
Categories
Funding
- Ministry Science & Technology of China [2006AA02A110]
- National Natural Science Foundation of China [30600238]
- Tianjin Municipal Science and Technology Commission [08ZCKFSF03200, 07JCYBJC11200]
Ask authors/readers for more resources
Atherosclerosis, an inflammatory process that selectively affects arteries, is highly prevalent in human. Thrombo-occlusive complications of atherosclerosis, including stroke and myocardial infarction, are becoming major causes of morbidity and mortality in the industrialized world. Atherosclerosis develops in response to local endothelial injuries. Endothelial dysfunction and cell loss are prominent features in atherosclerosis. Restoring the endothelial lining to normal is critical for slowing or reversing the progression of atherosclerosis. Increasing data suggest that endothelial progenitor cells (EPCs) play a significant role in reendothelialization of the injured blood vessels. This review focuses on the effects of EPC mobilization and transfusion in the condition of atherosclerosis. The aim of the review is to provide an update on the progress in this research field, highlight the role of EPCs in atherosclerosis and discuss the possible mechanisms and potential risks of progenitor cell-based therapy in atherosclerosis. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available