Journal
AGE
Volume 36, Issue 4, Pages -Publisher
SPRINGER
DOI: 10.1007/s11357-014-9675-7
Keywords
alpha(1)-Adrenergic receptor; Aging; Longevity; Cancer; Norepinephrine
Categories
Funding
- American Physiological Society Undergraduate Research Fellowship
- University of North Dakota School of Medicine and Health Sciences Undergraduate Research Fellowship
- National Science Foundation Graduate Research Fellowship [DGE-0950693]
- National Science Foundation [0851869]
- Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health [P20 GM103442]
- National Institute of Heart, Lung, and Blood [R01-HL098279]
- Direct For Biological Sciences
- Div Of Biological Infrastructure [0851869] Funding Source: National Science Foundation
- Div Of Biological Infrastructure
- Direct For Biological Sciences [1359243] Funding Source: National Science Foundation
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The alpha(1)-adrenergic receptor (alpha(1)AR) subtypes, alpha(1A)AR and alpha(1B)AR, have differential effects in the heart and central nervous system. Long-term stimulation of the alpha(1A)AR subtype prolongs lifespan and provides cardio- and neuro-protective effects. We examined the lifespan of constitutively active mutant (CAM)-alpha(1B)AR mice and the incidence of cancer in mice expressing the CAM form of either the alpha(1A)AR (CAM-alpha(1A)AR mice) or alpha(1B)AR. CAM-alpha(1B)AR mice have a significantly shortened lifespan when compared with wild-type (WT) animals; however, the effect was sex dependent. Female CAM-alpha(1B)AR mice lived significantly shorter lives, while the median lifespan of male CAM-alpha(1B)AR mice was not different when compared with that of WT animals. There was no difference in the incidence of cancer in either sex of CAM-alpha(1B)AR mice. The incidence of cancer was significantly decreased in CAM-alpha(1A)AR mice when compared with that in WT, and no sex-dependent effects were observed. Further study is warranted on cancer incidence after activation of each alpha(1)AR subtype and the effect of sex on lifespan following activation of the alpha(1B)AR. The implications of a decrease in cancer incidence following long-term alpha(1A)AR stimulation could lead to improved treatments for cancer.
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