Journal
AGE
Volume 31, Issue 4, Pages 327-341Publisher
SPRINGER
DOI: 10.1007/s11357-009-9104-5
Keywords
Dietary restriction; Sirt1; Resveratrol; Epigenetics; DNA methylation; Histone acetylation
Categories
Funding
- BBSRC [BB/E007457/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [GR/T26580/01] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/E007457/1] Funding Source: Medline
Ask authors/readers for more resources
Dietary restriction (DR) increases lifespan in a range of evolutionarily distinct species. The polyphenol resveratrol may be a dietary mimetic of some effects of DR. The pivotal role of the mammalian histone deacetylase (HDAC) Sirt1, and its homologue in other organisms, in mediating the effects of both DR and resveratrol on lifespan/ageing suggests it may be the common conduit through which these dietary interventions influence ageing. We propose the novel hypothesis that effects of DR relevant to lifespan extension include maintenance of DNA methylation patterns through Sirt1-mediated epigenetic effects, and proffer the view that dietary components, including resveratrol, may mimic these actions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available