Journal
AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY
Volume 5, Issue 3, Pages 415-420Publisher
ACADEMIC JOURNALS
DOI: 10.5897/AJPP11.089
Keywords
Immunomodulating; Dendrobium denneanum; polysaccharide; anti-tumor
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Funding
- Education Department Foundation of Sichuan Province of China [08ZA074]
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Three water-soluble polysaccharides (DDP1-1, DDP2-1 and DDP3-1) were obtained from the aqueous extracts of the stems of Dendrobium denneanum by hot water extraction, ethanol precipitation, and fractionated by DEAE-cellulose ion exchange chromatography and Sephadex G-200 gel filtration chromatography. The main structure characterizations and anti-tumor activities of three fractions were evaluated in this paper. The results showed DDP1-1 with 12.50 mg/kg could significant inhibit the increment of the tumor, increase immune index of S180 mice, and also strongly promote the secretion of IL-2, TNF-alpha and IFN-gamma. Therefore, results of these studies demonstrated the polysaccharide DDP1-1 has strong anti-tumor and immunomodulation abilities.
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