Journal
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Volume 50, Issue 10, Pages 4719-4726Publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/iovs.08-3289
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Funding
- National Eye Institute [R01-EY011610]
- Glaucoma Research Foundation
- American Health Assistance Foundation
- Legacy Good Samaritan Foundation
- Heidelberg Engineering
- GmbH
- Heidelberg, Germany
- Carl Zeiss Meditec, Inc
- Royal College of Ophthalmologists/Pfizer Fellowship
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PURPOSE. To determine whether acutely elevated intraocular pressure (IOP) alters peripapillary retinal thickness, retinal nerve fiber layer thickness (RNFLT), or retardance. METHODS. Nine adult nonhuman primates were studied while under isoflurane anesthesia. Retinal and RNFLTs were measured by spectral domain optical coherence tomography 30 minutes after IOP was set to 10 mm Hg and 60 minutes after IOP was set to 45 mm Hg. RNFL retardance was measured by scanning laser polarimetry in 10-minute intervals for 30 minutes while IOP was 10 mm Hg, then for 60 minutes while IOP was 45 mm Hg, then for another 30 minutes after IOP was returned to 10 mm Hg. RESULTS. RNFLT measured 1120 mu m from the ONH center decreased from 118.1 +/- 9.3 mu m at an IOP of 10 mm Hg to 116.5 +/- 8.4 mu m at 45 mm Hg, or by 1.4% +/- 1.8% (P < 0.0001). There was a significant interaction between IOP and eccentricity (P < 0.0006). Within 800 mu m of the ONH center, the RNFL was 4.9% +/- 3.4% thinner 60 minutes after IOP elevation to 45 mm Hg (P < 0.001), but unchanged for larger eccentricities. The same pattern was observed for retinal thickness, with 1.1% +/- 0.8% thinning overall at 45 mm Hg (P < 0.0001), and a significant effect of eccentricity (P < 0.0001) whereby the retina was 4.8% +/- 1.2% thinner (P < 0.001) within 800 mu m, but unchanged beyond that. Retardance increased by a maximum of 2.2% +/- 1.1% 60 minutes after IOP was increased to 45 mm Hg (P = 0.0031). CONCLUSIONS. The effects of acute IOP elevation on retinal thickness, RNFL thickness and retardance were minor, limited to the immediate ONH surround and unlikely to have meaningful clinical impact. (Invest Ophthalmol Vis Sci. 2009;50: 4719-4726) DOI: 10.1167/iovs.08-3289
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