Journal
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
Volume 85, Issue 1-2, Pages 61-69Publisher
VERLAG HANS HUBER
DOI: 10.1024/0300-9831/a000227
Keywords
vitamin D; fortified yogurt drink; bone; diabetes
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Funding
- National Nutrition and Food Technology Research Institute (NNFTRI)
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Introduction: There is sparse evidence of the effect of vitamin D on bone biomarkers in diabetic patients, and therefore, in a randomized clinical trial, we evaluated the effects of the daily intake of vitamin D, either with or without extra calcium, on selected bone biomarkers. Materials and Methods: Ninety women and men aged 30-50 years old with type 2 diabetes were randomly divided into three groups in a double-blind manner. Group 1 (PD), the control group, received a plain yogurt drink. Groups 2 (DD) and 3 (CDD) received 1000 IU vitamin D3, and 1000 IU vitamin D3 plus 500 mg calcium, respectively, via drinking two 250 mL bottles a day of a fortified yogurt drink for twelve weeks. Anthropometric and biochemical assessments were made, including 25(OH), intact parathyroid hormone (iPTH), osteocalcin, and calcium. Results: Although the time and timexgroup interaction effects on the bone biomarkers were not statistically significant, there was a modest decrease in iPTH concentrations in both DD and CDD groups over twelve weeks. The subgroups with initial vitamin D deficiency/insufficiency in the CDD group had greater and significant decrease in serum iPTH concentrations after twelve weeks of treatment compared to the PD group (-9.0 +/- 21.2 v.s 8.6 +/- 21.8 pg/mL, p = 0.042). Conclusion: The improvement in vitamin D status following the daily intake of fortified doogh for twelve weeks was accompanied by a decrement in iPTH, mostly in those subjects with poor initial vitamin D status.
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