Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 45, Issue 4, Pages 203-207Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2014.12.006
Keywords
Atherosclerosis; ES-62; Helminth; Systemic lupus erythematosus
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Funding
- Wellcome Trust, UK [086852]
- National Institutes of Health (NIH), USA [PO1 R050256]
- US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)/NIH [K01 AR055965-02]
- NIAMS/NIH [R21 AR063387-01]
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ES-62 is an anti-inflammatory phosphorylcholine-containing glycoprotein secreted by the filarial nematode Acanthocheilonema viteae. Accelerated atherosclerosis frequently occurs in systemic lupus eiythematosus, resulting in substantial cardiovascular morbidity and mortality. We examined the effects of ES-62 in the gld.apoE(-/-) mouse model of this condition. Treatment with ES-62 did not substantially modulate renal pathology but caused decreased anti-nuclear autoantibody levels. Moreover, a striking 60% reduction in aortic atherosclerotic lesions was observed, with an associated decrease in macrophages and fibrosis. We believe that these latter findings constitute the first example of a defined parasitic worm product with therapeutic potential in atherosclerosis: ES-62-based drugs may represent a novel approach to control accelerated atherosclerosis in systemic lupus erythematosus. (C) 2015 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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