Journal
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
Volume 39, Issue 11, Pages 1542-1551Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-009-0794-4
Keywords
Autism; Autism spectrum disorder; Anxiety; Attention-deficit hyperactivity disorder; Tourette syndrome; BDNF; COMT; DAT1
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The aim of the study is to examine rs4680 (COMT) and rs6265 (BDNF) as genetic markers of anxiety, ADHD, and tics. Parents and teachers completed a DSM-IV-referenced rating scale for a total sample of 67 children with autism spectrum disorder (ASD). Both COMT (p = 0.06) and BDNF (p = 0.07) genotypes were marginally significant for teacher ratings of social phobia (eta p(2) = 0.06). Analyses also indicated associations of BDNF genotype with parent-rated ADHD (p = 0.01, eta p(2) = 0.10) and teacher-rated tics (p = 0.04; eta p(2) = 0.07). There was also evidence of a possible interaction (p = 0.02, eta p(2) = 0.09) of BDNF genotype with DAT1 3' VNTR with tic severity. BDNF and COMT may be bio-markers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples.
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